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The activation of the A2B receptor subtype suppresses the prenylation of the small guanosine triphosphatase (GTPase) RAS related protein 1 (RAP1), which is involved in the formation and maintenance of cell adherens junctions. This suppression leads to a reduced cell adhesion and to a subsequent increase of cell scattering. In addition, exosomes produced by cancer cells express CD39 and CD73 enzymes.

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